Papers

Below are the publications this lab has been associated with. Click the links to open the publications in a new window. For a full list please visit PubMed.

 

  • A single mutant, A276S of p53, turns the switch to apoptosis. Reaz S, Mossalam M, Okal A, Lim CS. Mol Pharm. 2013 Apr 1;10(4):1350-9. PDF

 

  • Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2.Davis JR, Mossalam M, Lim CS. Mol Pharm. 2013 Apr 1;10(4):1340-9. PDF

 

  • Disrupting BCR-ABL in Combination with Secondary Leukemia-Specific Pathways in CML Cells Leads to Enhanced Apoptosis and Decreased Proliferation. Woessner, DW, Lim, CS. Mol Pharm. 2013 Jan 7;10(1):270-7. PDF

 

  • Enhanced and Selective Killing of Chronic Myelogenous Leukemia Cells with an Engineered BCR-ABL Binding Protein and Imatinib. Constance, JE, Woessner, DW, Matissek, KM, Mossalam, M, Lim CS. Mol Pharm. 2012 Nov 5;9(11):3318-29. PDF

 

  • Targeting malignant mitochondria with therapeutic peptides. Constance JE, Lim CS. Ther Deliv. 2012 Aug;3(8):961-79. Review.

 

  • Utilizing the estrogen receptor ligand-binding domain for controlled protein translocation to the insoluble fraction. Davis JR, Mossalam M, Lim CS. Pharm Res. 2012 Dec;29(12):3455-63. PDF

 

  • Direct induction of apoptosis using an optimal mitochondrially targeted p53.Mossalam M, Matissek KJ, Okal A, Constance JE, Lim CS. Mol Pharm. 2012 May 7;9(5):1449-58.PDF.

 

  • Changing the subcellular location of the oncoprotein Bcr-Abl using rationally designed capture motifs. Dixon AS, Constance JE, Tanaka T, Rabbitts TH, Lim CS. Pharm Res. 2012 Apr;29(4):1098-109.  PDF.

 

  • Selective Targeting of c-Abl via a Cryptic Mitochondrial Targeting Signal Activated by Cellular Redox Status in Leukemic and Breast Cancer Cells. Constance JE, Despres SD, Nishida A, Lim CS. Pharm Res. 2012 Aug;29(8):2317-28.  PDF

 

  • Improved coiled-coil design enhances interaction with Bcr-Abl and induces apoptosis.Dixon AS, Miller GD, Bruno BJ, Constance JE, Woessner DW, Fidler TP, Robertson JC, Cheatham TE 3rd, Lim CS. Mol Pharm. 2012 Jan 1;9(1):187-95. PDF. Correction.

 

  • Development of an Effective Therapy for CML. Woesser, D.W., Lim, C.S., and Deininger, M.W. Cancer J. 2011 Nov-Dec;17(6):477-86. PDF.

 

  • Disruption of Bcr-Abl Coiled-Coil Oligomerization by Design. Dixon, A.S., Pendley, S.S., Bruno, B.J., Woessner, D.W., Shimpi, A.A., Cheatham, T.E., III, and Lim, C.S. Journal of Biological Chemistry, 2011 Aug 5;286(31):27751-60. Epub 2011 Jun 9. PDF

 

  • “Choosing Targets for Gene Therapy” in the book Targets for Gene Therapy. Matissek, K.J., Bender, R.R., Davis, J.R., and Lim, C.S. published by Intech Open Access Publisher, July 2011, ISBN 978-953-307-540-2. LINK

 

  • The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications. Cadwallader, A.B., Botre, F., Lim, C.S., and Rollins, D.E. The Journal of Analytical Toxicology, 2011, 35(9): 594-607. PDF

 

  • Controlling subcellular delivery to optimize therapeutic effect. Mossalam M, Dixon AS, Lim CS. Therapeutic Delivery (2010) 1(1), 169–193. PDF

 

  • The nuclear translocation assay for intracellular protein-protein interactions and its application to the Bcr coiled-coil domain. Dixon AS, Lim CS. Biotechniques. 2010 Jul;49(1):519-24. PDF

 

  • Effect of anabolic-androgenic steroids and glucocorticoids on the kinetics of hAR and hGR nucleocytoplasmic translocation. Cadwallader AB, Rollins DE, Lim CS. Mol Pharm. 2010 Jun 7;7(3):689-98.PDF

 

  • Controlling subcellular localization to alter function: Sending oncogenic Bcr-Abl to the nucleus causes apoptosis.Dixon AS, Kakar M, Schneider KM, Constance JE, Paullin BC, Lim CS. J Control Release. 2009 Dec 16;140(3):245-9. Epub 2009 Jul 1.PDF

 

  • Signal sequences for targeting of gene therapy products to subcellular compartments: the role of CRM1 in nucleocytoplasmic shuttling of the protein switch. Kakar M, Cadwallader AB, Davis JR, Lim CS. Pharm Res. 2007 Nov;24(11):2146-55. Epub 2007 Jun 13. PDF

 

  • Optimizing the protein switch: altering nuclear import and export signals, and ligand binding domain. Kakar M, Davis JR, Kern SE, Lim CS. J Control Release. 2007 Jul 31;120(3):220-32. Epub 2007 May 3. PDF